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Objective:Based on the theory of demand analysis theory, to build teaching resources of human physiology course and explore its application effect.Methods:The three-year nursing junior college students of Batch 2018 were selected as the research objects. According to the principle of randomization, the students were divided into the observation group (97 cases) and control group (99 cases). Students in the observation group used integrated teaching resources from the perspective of demand analysis, while students in the control group used traditional curriculum resources. After the end of the course, the differences between the two groups of students' theoretical and practical assessment results and teaching experience were compared SPSS 20.0 was used for t test. Results:The results of theoretical [(73.67±8.76) vs. (70.48±8.36)] and practical skills [(84.41±4.83) vs. (83.63±4.27)] in the observation group were significantly different from those in the control group ( P<0.05). The overall scores of 9 teaching effect sub-items, such as learning awareness of inquiry, independent learning ability and critical thinking ability, were significantly higher than those of the control group ( P<0.01). Conclusion:The construction of human physiology teaching resources based on demand analysis theory can improve the effectiveness and pertinence of resource construction, and the effective use of resources in teaching can significantly improve the teaching effect, stimulate students' subjective initiative, cultivate their comprehensive ability and improve classroom efficiency.
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Multiple primary malignancies (MPMs) are two or more primary malignancies diagnosed in the same patient at the same time or at a specific time and do not represent progression, recurrence or metastasis of the first tumor.MPMs are extremely rare. In this paper, we reported a case of male patient who was diagnosed with invasive uroepithelial carcinoma, rectal adenocarcinoma, clear cell renal cell carcinoma and sarcomatoid carcinoma of the bladder, and open partial cystectomy, laparoscopic radical operation for rectal cancer, laparoscopic partial left nephrectomy, transurethral resection of bladder tumor and laparoscopic radical cystectomy with ureterostomy were performed, respectively.The patient was followed up for 16 months after the last surgery, with good general condition and no recurrence or metastasis.
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Objective:To analyze the risk factors of nosocomial infection after craniocerebral trauma.Methods:From June 2016 to June 2019, 314 patients with craniocerebral injury admitted to Dajiangdong Hospital were treated with surgical operation.According to whether infection occurred after operation, they were divided into infection group ( n=29) and uninfected group ( n=285). Multivariate logistic regression was used to analyze the risk factors of nosocomial infection after craniocerebral injury. Results:Of 314 patients with craniocerebral injury, 29 cases (9.24%) had postoperative nosocomial infection.Single factor analysis showed that there were no significant differences between the two groups in gender, hypertension and injury type (all P>0.05). The proportion of age>60 years old in the infected group (15.91%) was higher than that in the uninfected group (4.40%), the proportion of diabetes mellitus in the infected group(26.23%) was higher than that in the uninfected group (8.50%), the proportion of preoperative GCS score<8 points in the infected group(15.75%) was higher than that in the uninfected group (4.81%), and the proportion of operation time>10 d in the infected group(14.09%) was higher than that in the uninfected group (4.85%), invasive operation rate in the infected group(19.49%) was higher than in the uninfected group (3.06%), CSF leakage rate in the infected group(19.15%) was higher than in the uninfected group(5.00%), extraventricular drainage rate in the infected group(25.00%) was higher than than in the uninfected group (4.20%), the differences were statistically significant (χ 2=12.099, 11.706, 10.789, 5.954, 7.984, 23.720, 15.728, 29.726, all P<0.05). The logistic regression analysis showed that age>60 years old, complicated with diabetes mellitus, preoperative GCS score<8 points, operation time>3 h, hospital stay>10 d, invasive operation, CSF leakage and ventricular drainage were the risk factors of postoperative hospital infection. Conclusion:Nosocomial infection after craniocerebral trauma is affected by many factors, including age, diabetes mellitus, preoperative GCS score, operation time, hospitalization time, invasive operation, cerebrospinal fluid leakage and extraventricular drainage.
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Objective To explore the effects of improved pterion approach on neurological function and prognosis of patients with craniocerebral trauma.Methods From July 2014 to July 2016,100 patients with craniocerebral trauma admitted to Hangzhou Dajiang East Hospital were selected in this study,and they were divided into two groups according to different surgical methods,with 50 cases in each group.The control group was given traditional surgical approach,and the observation group was given improved pterion approach surgery.The neurological function,safety and prognosis of the two groups were observed.Results The NDS scores and GCS scores had no statistically significant differences between the two groups before treatment (t =1.03,0.98,all P ＞ 0.05).After treatment,the NDS scores of the two groups were significantly reduced (t =5.62,7.23,all P ＜ 0.05),the GCS scores of the two groups were significantly improved(t =3.46,4.75,all P ＜ 0.05).The NDS score of the observation group was (13.72 ± 5.42) points,which was significantly lower than that of the control group [(20.72 ± 6.51) points] (t =4.32,P ＜ 0.05).The GCS score of the observation group was (l 1.25 ± 2.63) points,which was significantly higher than that of the control group [(8.42 ± 1.35) points] (t =3.27,P ＜ 0.05).The incidence rate of complications of the control group was significantly higher than that of the observation group [48％ (24/50) vs.18％ (9/50),x2 =7.36,P ＜ 0.05].The mortality rate of the control group was significantly higher than that of the observation group [32％(15/50) vs.16％ (8/50),x2 =3.17,P ＜ 0.05],and the recovery rate of the control group was significantly lower than that of the observation group [14％ (7/50) vs.28％ (14/50),x2 =6.35,P ＜ 0.05].Before treatment,there were no statistically significant differences in the Spitzer index between the two groups(t =1.01,0.98,0.92,0.98,0.87,all P ＜ 0.05).After treatment,the Spitzer index of the two groups were significantly higher than those before treatment (t =2.72,3.64,2.83,3.45,3.52,3.67,3.84,4.61,4.53,5.27,all P ＜ 0.05),which of the observation group were significantly higher than those of the control group (t =2.56,2.73,4.26,4.43,3.95,all P ＜ 0.05).Conclusion The improved pterion approach in the treatment of patients with craniocerebral trauma has better neural functional recovery than traditional surgery,and it has lower mortality rate and complication rate,better security,and can encourage patients to improve the quality of life,and it has better prognosis.
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Objective@#To explore the effects of improved pterion approach on neurological function and prognosis of patients with craniocerebral trauma.@*Methods@#From July 2014 to July 2016, 100 patients with craniocerebral trauma admitted to Hangzhou Dajiang East Hospital were selected in this study, and they were divided into two groups according to different surgical methods, with 50 cases in each group.The control group was given traditional surgical approach, and the observation group was given improved pterion approach surgery.The neurological function, safety and prognosis of the two groups were observed.@*Results@#The NDS scores and GCS scores had no statistically significant differences between the two groups before treatment(t=1.03, 0.98, all P>0.05). After treatment, the NDS scores of the two groups were significantly reduced(t=5.62, 7.23, all P<0.05), the GCS scores of the two groups were significantly improved(t=3.46, 4.75, all P<0.05). The NDS score of the observation group was (13.72±5.42)points, which was significantly lower than that of the control group[(20.72±6.51)points](t=4.32, P<0.05). The GCS score of the observation group was (11.25±2.63)points, which was significantly higher than that of the control group[(8.42±1.35)points](t=3.27, P<0.05). The incidence rate of complications of the control group was significantly higher than that of the observation group[48%(24/50) vs.18%(9/50), χ2=7.36, P<0.05]. The mortality rate of the control group was significantly higher than that of the observation group[32%(15/50) vs.16%(8/50), χ2=3.17, P<0.05], and the recovery rate of the control group was significantly lower than that of the observation group[14%(7/50) vs.28%(14/50), χ2=6.35, P<0.05]. Before treatment, there were no statistically significant differences in the Spitzer index between the two groups(t=1.01, 0.98, 0.92, 0.98, 0.87, all P<0.05). After treatment, the Spitzer index of the two groups were significantly higher than those before treatment(t=2.72, 3.64, 2.83, 3.45, 3.52, 3.67, 3.84, 4.61, 4.53, 5.27, all P<0.05), which of the observation group were significantly higher than those of the control group(t=2.56, 2.73, 4.26, 4.43, 3.95, all P<0.05).@*Conclusion@#The improved pterion approach in the treatment of patients with craniocerebral trauma has better neural functional recovery than traditional surgery, and it has lower mortality rate and complication rate, better security, and can encourage patients to improve the quality of life, and it has better prognosis.
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<p><b>OBJECTIVE</b>To evaluate the feasibility of endoscopic lobectomy for pulmonary sequestration in children.</p><p><b>METHODS</b>Clinical data of 47 children with pulmonary sequestration treated with endoscopic lobectomy from April 2015 to November 2017 were reviewed. According to the operation date, 19 children received operation from April 2015 to December 2016 were early group, and 23 children received operation from January 2017 to November 2017 were late group (5 children with lesions inside diaphragm were excluded). The operation time, intraoperative blood loss, retention time of drainage tube, length of hospital stay and incidence of complications were compared between two groups.</p><p><b>RESULTS</b>Among 47 children, endoscopic lobectomy was successfully completed in 45 children, and the rest 2 children were converted to thoracotomy. No death was observed. The operation time in late group was shorter than that in the early group (<0.05), and the intraoperative blood loss of the late group was less than that of early group (<0.05); while there were no significant differences in retention time of drainage tube and length of hospital stay between two groups (both >0.05). Postoperative complications occurred in 14 children, including 4 cases of pneumothorax, 8 cases of pleural effusion, 1 case of pulmonary infection, and 1 case of diaphragmatic hernia. The incidence rates of postoperative complications in late group and early group were 17.4% (4/23) and 42.1% (8/19), and the difference was not statistically significant(>0.05). During the follow-up (2-26 months), no relapse and thoracic collapes were observed, and CT examination found that the remaining lungs were well compensated in all children.</p><p><b>CONCLUSIONS</b>The endoscopic lobectomy is effective and safe with less trauma and bleeding, which is recommended for treatment of pulmonary sequestration in children.</p>
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Objective: To explore influence of short-term intervention of different doses rosuvastatin on plasma levels of thrombomodulin (TM) and high sensitive C reactive protein (hsCRP) in patients with acute coronary syndrome (ACS). Methods: A total of 32 ACS patients were enrolled, randomly and equally divided into rosuvastatin 10mg group and rosuvastatin 20mg group, and another 16 patients without coronary heart disease were enrolled as normal control group. Enzyme linked immunosorbent assay (ELISA) was used to measure plasma levels of TM and hsCRP in two rosuvastatin groups before and after treatment and in normal control group at admission. Adverse drug reactions and incidence rates of cardiovascular events within one month were observed in two rosuvastatin groups. Results: Plasma levels of TM and hsCRP in two groups of ACS patients were both significantly higher than those of normal control group before treatment, P0.05); compared with rosuvastatin 10mg group, there was significant decrease in incidence rate of major adverse cardiovascular events（MACE）: Relapse angina pectoris (62.50% vs. 18.75%, P<0.01) in rosuvastatin 20mg group. Conclusions: Early intensive statins medication （rosuvastatin 20mg）can decrease plasma levels of thrombomodulin and high sensitive C reactive protein, and rosuvastatin 20mg/d can effectively decrease incidence rate of cardiovascular events without significant increase incidence rate of adverse drug reactions in ACS patients.
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Objective To investigate the effects of the serum from rats with hemorrhagic shock and Shenfu injection, on the expression of endothelial cell protein C receptor (EPCR) in human umbilical vein endothelial cells (HUVECs) cultured with rat serum. Method The soluble endothelial protein C receptor (sEPCR) in supernatant, the expression of EPCR mRNA and protein level of EPCR in HUVECs were detected by using enzyme linked immunosorbent assay ( ELISA), reverse transcription polymerase chain reaction (RT-PCR), and western bloting (WB) in normal control group, hemorrhagic shock serum (3 h, 12 h, 24h, 72 h) group, and Shenfu-treated (3 h, 12 h, 24 h, 72 h) group, respectively. Results The mean levels of sEPCR and the expression of EPCR mRNA were significantly higher in hemorrhagic shock serum (12 h, 24 h) group, and Shenfu -treated(24 h)group than those in normal control group (all P ＜0.01 ),the mean levels of sEPCR and the expressions of EPCR mRNA were significantly higher in Shenfu-treated ( 12 h) group than those in normal control group ( all P ＜0. 05 ), while the levels of protein were lower in hemorrhagic shock serum ( 12 h, 24 h) group and in Shenfu-treated(24 h)group than those in normal control group ( both P ＜0.01 ), and the level of EPCR protein was lower in Shenfu-treated( 12 h) group than that in normal control group ( P ＜ 0. 05) . The mean levels of sEPCR and the expressions of EPCR mRNA were significantly lower in Shenfu-treated ( 12 h, 24 h) group than those in hemorrhagic shock serum ( 12 h,24 h) group (all P ＜0.05), while the levels of EPCR protein were higher in Shenfu-treated ( 12 h, 24 h)group than those in hemorrhagic shock serum ( 12 h, 24 h) group ( P ＜ 0.05 ). Conclusions These data suggest that Shenfu injectio could affect the expression of EPCR mRNA and the level of EPCR protein, thereby it might be effective in prevention of development of hemorrhagic shock.
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Enterprise resource planning is systematic management thought and means established on the basis of information technology,which provides management platform for the decision-makers and staffs to make the decisions.By using IT technology,ERP closely integrates material flow,information flow,capital flow,management flow,and knowledge flow of a enterprise,which facilitates resource optimization and sharing.ERP can be introduced into the hospital drug management.Using advanced information and logistics technology,hospital drug mannagement can be strengthened on such aspects as drug purchase,drug storehouse management,dispensing management in pharmacy,capital settlement and rational use of drug,and so on.Therefore,the hospital drug management can be improved by achieving planning in advance,real-time tracing back,effective control and rational use.
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Objective To develop an anion-exchange chromatographic method for the determination of trace thiocyanate and iodide. Methods A sample containing thiocyanate and iodide was pumped through a continuous rod anion-exchange column and the two anions were eluted subsequently with potassium bromide and were determined by a UV detector simultaneously. Results It was proved that the chromatographic column could separate thiocyanate and iodide effectively in the optimum conditions. The linear equation of iodide was y=3 272 860x+51 929.537 57, r=0.999 03, the final detection range was 0.30-3.0 mmol/L, the detection limit was 1.27 ?g/L, the recovery rate was 87% and RSD was 2.75%, the linear equation of thiocyanate was y=3 163 690 x+1 057 080, r=0.999 49, the final detection range was 5.0-80 mmol/L, the detection limit was 30 ?g/L, the recovery rate was 85% and RSD was 3.22%. Conclusion This method is simple, reliable, better anti-interference and is applicable to the determination of trace thiocyanate and iodide.
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OBJECTIVE:To reduce drug dispensing mistakes and the hidden dangers in outpatient dispensary so as to improve the quality of drug dispensing.METHODS:The corresponding intervention measures were taken based on the analysis on drug dispensing mistakes and the hidden dangers in outpatient dispensary,meanwhile the state after intervention was compared with that before.RESULTS:The drug dispensing mistakes decreased from40cases to16cases with the decreasing rate at60%after intervention;and the hidden dangers of mistakes has decreased from178cases to118cases with the decrease rate at33.7%.CONCLUSION:The drug dispensing mistakes and the hidden dangers in outpatient dispensary have been de?creased effectively and the quality of drug dispensing has been improved through the practice of the comprehensive precau?tionary measures.
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OBJECTIVE To develope an HPLC assay for the determination of tanshinoneⅡA.METHOD C18ODS column was used.The mobile phase was consisted of MeOH-water(70∶30).The detection wavelength was at 269 nm.RESULT The linear regression equation was Y=9725X-2584,r=0.9997.The average recovery was 98.29% with RSD=1.86%.(n=5).CONCLUSION The method may be used for quality control.
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Using the teaching resources on the network completely, apply them, which have been put in order, revised, improved and replenished, to the teaching of microbiology, and raise the teaching quality and efficiency of microbiology